BİOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Senem Heper

 

 

Title:  PhD. Student in Biotechnology, METU, 2014
Education: 

M.Sc. Biotechnology, METU

B.Sc. Biochemistry, Ege University, 2011

Contact:  Telephone:  +90 312 210 5189
e-mail: senem.heper @gmail.com

 

 

Research Field: 


  • Current Research Activities

Patient-Specific Orthopedic Implant Design and Production with Tissue Engineering

Method: The aim of this project is to design and produce patient specific orthopedic implants via tissue engineering. In recent years, the trend in the orthopedic treatments has been shifting to the patient specific implant design instead of the application of any commercially available implant. This will especially be helpful in eliminating the trial-and-error approach for size determination in operating theater. Besides, this will avoid the modification of the implat in during surgery when the standard implant cannot be used. Tissue engineering, on the other hand, is one of the therapy methods emerging in recent years which aim effective and rapid healing by developing tissues on porous scaffolds using patient’s cells and applying the partially developed tissue to the defect area. Design and production of three dimensional (3D) implants that will fit to the defect site is now possible with the combination of new technologies like computed tomography (CT), rapid prototyping (RP) or similar techniques. In this study, cylindrical disks of poly(ε-caprolactone) (PCL) was printed by fused deposition modeling and modified with nanohydroxyapatite (HAp) and poly(propylene fumarate) (PPF) to create a mechanically strong implant with well-defined pore size and porosity, controllable surface hydrophilicity and osteoconductivity.

 

  • MSc. Thesis 

Controlled Doxorubicin Delivery from Photoresponsive Liposomes Carrying Vitamin A Derivatives: The aim of this study was to develop photoresponsive liposomes for the treatment of ocular diseases that required frequent and continuous drug application. In the study, photoresponsive liposomes were prepared by incorporating vitamin A derivatives into the lipid bilayer of the liposomes for use in treatment of eye diseases that require frequent and continuous drug administration. Proliferative vitreoretinopathy was selected as a model disease and doxorubicin as the therapeutic agent. Doxorubicin loaded phosphatidyl choline (PC): cholesterol (CHOL): all-trans retinal (ATR) (7:1:3) liposomes were tested on RPE/D407 cells to determine the effect of UVA exposure (365 nm) on the release of doxorubicin, and therefore, cell viability.


Projects:

  • TÜBİTAK 215M621, Development of A Bone Tumor Model with 3D Printed and Lyophilized Scaffolds, Scholarship, July 2016-Continue
  • TÜBİTAK 213M708, Patient-specific orthopedic implant design and production with tissue engineering method, 1003, Scholarship, October 2014 – June 2016
  • TÜBİTAK 113S471, Design and Development of Implantable Neurostimulation/ Neuromodulation Devices, 1003, Scholarship, January 2014 - September 2014


Selected Publications:

  • Buyuksungur, S., Endogan, T. T., Buyuksungur, A., Bektas, E. I., Torun, K. G., Yucel, D.,  Beyzadeoglu T., Cetinkaya E., Yenigun C., Tönük E., Hasirci V., Hasirci, N. (2017). 3D printed poly(ε-caprolactone) scaffolds modified with hydroxyapatite and poly(propylene fumarate) and their effects on the healing of rabbit femur defects. Biomaterials science. DOI: 10.1039/C7BM00514H.
  • Polat, G. G., Akgun, O. M., Simsek, B., Saracli, M. A., Heper, S., and Hasirci, V. (2016). Fluoride-Contaınıng Antı-Carıes Ph-Sensıtıve Release System And Its Effect On Streptococcus Mutans. Fluoride 49:458-466


Presentations:

  • Buyuksungur, S., Endogan, T. T., Buyuksungur, A., Bektas, E. I., Torun, K. G., Yucel, D.,  Beyzadeoglu T., Cetinkaya E., Yenigun C., Tönük E., Hasirci V., Hasirci, N., Polymeric composites with multifunctional properties and 3D bioplotted scaffolds for tissue engineering applications, 28th European Conference on Biomaterials, 4th – 8th September 2017 Athens, Greece. (Presented by NH)
  • Buyuksungur A., Buyuksungur S., Hasirci N., Hasirci H., 3 Boyutlu Hastaya Özel Biyobozunur Kemik İmplantlarının Tasarımı ve Karekterizasyonu, Micro CT Summer School, 30 -03 June 2016, Malatya, Turkey. (Presented by AB)
  • Buyuksungur A., Hasirci N., Hasirci H., Buyuksungur S. Biyobasım sonrası implant görüntülemesi: Mikro CT, Doku Mühendisliğinde Biyobasım: Polimerik Malzemeler, Biyoseramik Kompozitler, Doku Özdeşleri, 02 November 2016, Kocaeli University, Kocaeli, Turkey. (Presented by AB)
  • Buyuksungur S., Hasirci N., Hasirci V., (2015). Controlled Doxorubicin Delivery from Photoresponsive Liposomes Carrying Vitamin A Derivatives. 21st Biomaterials Science and Technology Symposium (BIOMED 2015), Antalya, Turkey. (Poster presentation)
  • Buyuksungur S., Buyuksungur A., Hasirci N., Hasirci V., (2015). 3D Printed, Tissue Engineered Femoral Implant Design and Production. 21st Biomaterials Science and Technology Symposium (BIOMED 2015) Antalya, Turkey. (Poster presentation)
  • Komez A., Buyuksungur S., Hasirci V., Hasirci N., (2015). Synthesis of Polyurethane for Coating of Neurostimulator. 21st Biomaterials Science and Technology Symposium (BIOMED 2015) Antalya, Turkey. (Poster presentation)
  • Heper S., Hasirci N., Hasirci V., (2015). Patient-Specific Orthopedic Implant Design and Production with Tissue Engineering Method. FBPS ’15, 11th International Symposium on Frontiers in Biomedical Polymers, Riva del Garda, Italy. (Poster presentation)