BİOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Prof. Dr. Vasıf Hasırcı

Title:  Professor
Education:  Ph.D. University of Reading, 1976 
M.Sc. METU, 1973
B.Sc. METU, 1971
Contact:

Office: BIOMATEN

Biotechnology Research Unit Rm 101

Telephone: +90 312 210 5180      

Fax: +90 312 210 1542
e-mail: vhasirci@metu.edu.tr

 

Research Field

 

Biomaterials and Tissue Engineering:

 

Hydrogels, controlled drug (antibiotic, pain reliever, growth factor, anticancer agent) delivery, responsive systems and liposomes, tissue engineering (bone, cartilage, retinal pigment epithelial cells, cornea, nerve, cardiac tissue), biodegradable polymers, hard tissue repair, nanobiomaterials. 

 

Biotechnology:

 

Biosensors, bioreactors, biodegradation (pesticides, biopolymers)

 

Graduate program affiliation: 


Biology; Molecular Biology and Genetics; Biotechnology; Biomedical Engineering; 
Micro and Nanotechnology; Polymer Science and Technology 

 

Publications in refereed international journals:


2016


  • Polat, G.G., Akgun, O.M., Simsek, B., Saracli, M.A., Heper, S. & Hasirci, V. (2016) Fluoride-containing Anti-caries pH-sensitive Release System and Its Effect on Streptococcus Mutants. Fluoride 49(4 Pt 1):458-466
  • Hasturk, O., Sivas, A., Karasozen, B., Demirci, U., Hasirci, N., & Hasirci, V. (2016). Quantification of type, timing, and extent of cell body and nucleus deformations caused by the dimensions and hydrophilicity of square prism micropillars. Advanced Healthcare Materials 5 (23), 2972-2982
  • Pekozer, GG., Kose, GT., Hasirci, V. (2016). Influence of co-culture on osteogenesis and angiogenesis of bone marrow mesenchymal stem cells and aortic endothelial cells. Microvascular Research 108, 1-9, 1
  • Komez, A., Baran, ET., Erdem, U., Hasirci, N., & Hasirci, V. (2016). Construction of a patterned hydrogel—fibrous mat bilayer structure to mimic choroid and Bruch's membrane layers of retina. Journal of Biomedical Materials Research Part A 104 (9), 2166-2177
  • Ermis, M., Akkaynak, D., Chen, P., Demirci, U., Hasirci, V. (2016). A high throughput approach for analysis of cell nuclear deformability at single cell level. Scientific Reports 6
  • Hasirci, N., Kilic, C., Kömez, A., Bahcecioglu, G., Hasirci, V. (2016) Hydrogels in regenerative medicine. GELS HANDBOOK: Fundamentals, Properties and Applications Volume 2

 

2015


  • Eke, G., Goni-de-Cerio, F., Suarez-Merino, B., Hasirci, N., & Hasirci, V. (2015). Biocompatibility of Dead Sea Water and retinyl palmitate carrying poly(3-hydroxybutyrate-co-3-hydroxyvalerate) micro/nanoparticles designed for transdermal skin therapy. Journal of Bioactive and Compatible Polymers [PDF]
  • Kiziltay, A., Marcos-Fernandez, A., San Roman, J., Sousa, R. A., Reis, R. L., Hasirci, V., & Hasirci, N. (2013). Poly(ester-urethane) scaffolds: effect of structure on properties and osteogenic activity of stem cells. Journal of Tissue Engineering and Regenerative Medicine. [PDF]


2014


  • Bagherifam, S., Skjeldal, F. M., Griffiths, G., Mælandsmo, G. M., Engebråten, O., Nyström, B., Hasirci, V., Hasirci, N. (2014). pH-Responsive Nano Carriers for Doxorubicin Delivery. Pharmaceutical Research. doi:10.1007/s11095-014-1530-0 [PDF]

  • Endogan Tanir, T., Hasirci, V., & Hasirci, N. (2014). Preparation and characterization of Chitosan and PLGA-based scaffolds for tissue engineering applications. Polymer Composites,  doi:10.1002/pc.23100

  • Bagherifam, S., Griffiths, G. W., Mælandsmo, G. M., Nyström, B., Hasirci, V., & Hasirci, N. (2014). Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin. Journal of Microencapsulation, 1–9. doi:10.3109/02652048.2014.973073

  • Sezer, U. A., Billur, D., Huri, G., Huri, P. Y., Aksoy, E. A., Terzioglu, H., Konukseven, E., Hasirci, V., Hasirci, N. (2014). In Vivo Performance of Poly(ε-caprolactone) Constructs Loaded with Gentamicin Releasing Composite Microspheres for Use in Bone Regeneration. Journal of Biomaterials and Tissue Engineering, 4(10), 786–795. doi:10.1166/jbt.2014.1238

  • Ozgen O.,Hasirci V., Hasirci N. (2014) Effects of oxygen nitrogen  and argon plasmas on PMMA surfaces, Journal of Biomaterials and Tissue Engineering, J. Biomater. Tissue Eng., 4(6), 479-487

  • Aydemir Sezer, U., Arslantunali, D., Aksoy, E. A., Hasirci, V., & Hasirci, N. (2014). Poly(ε-caprolactone) composite scaffolds loaded with gentamicin-containing β-tricalcium phosphate/gelatin microspheres for bone tissue engineering applications. Journal of Applied Polymer Science, 131(8), n/a–n/a. doi:10.1002/app.40110

  • Saygun, I., Bal, V., Kızıltay, A., Huri, P. Y., Avcu, F., Üstün, K., Hasirci V., Hasirci, N. (2014). Proliferation and Differentiation of Mesenchymal Stem Cells in Chitosan Scaffolds Loaded with Nanocapsules Containing Bone Morphogenetic Proteins-4, Platelet-Derived Growth Factor and Insulin-Like Growth Factor 1. Journal of Biomaterials and Tissue Engineering, 4(3), 181–188. doi:10.1166/jbt.2014.1153

  • Arslantunali, D., Dursun, T., Yucel, D., Hasirci, N., Hasirci, V. (2014). Peripheral nerve conduits: Technology update. Medical Devices: Evidence and Research, 7, 405-242.[PDF]
  • Sayin, E., Baran, E.T., Hasirci, V. (2014). Protein-based materials in load-bearing tissue-engineering  applications. Regenerative Medicine, 9(5), 687–701. [PDF]
  • Kinikoglu, B., Damour, O., Hasirci, V. (2014). Tissue engineering of oral mucosa: a shared concept with skin. Journal of Artificial Organs. DOI: 10.1007/s10047-014-0798-5. [PDF]

  • Endogan-Tanir, T., Hasirci, V., Hasirci, N. (2014). Electrospinning of chitosan/poly (lactic acid-co-glycolic acid)/hydroxyapatite composite nanofibrous mats for tissue engineering applications. Polymer Bulletin. DOI:10.1007/s00289-014-1234-y. 
  • Karadas,O., Yucel, D., Kenar, H., Kose, G., Hasirci, V. (2014).  Collagen scaffolds with in situ-grown calcium phosphate for osteogenic differentiation of Wharton’s jelly and menstrual blood stem cells. Journal of Tissue Engineering And Regenerative Medicine, 8,534–545. 
  • Kilic, C., Girotti, A., Rodriguez-Cabello, J., C., Hasirci, V. (2014). A collagen-based corneal stroma substitute with micro-designed architecture. Biomaterial Science, 2, 318-329.
  • Halili A. N., Hasirci N., Hasirci V. (2014). A multilayer tissue engineered meniscus substitute. Journal of Material Science: Materials in Medicine, 25, 1195-1209.
  • Eke G., Kuzmina A., Goreva A., Shishatskaya E., Hasirci N., Hasirci V. In vitro and Transdermal Penetration of PHBV Micro/Nanoparticles. Journal of Materials Science: Materials in Medicine. 2014. DOI:10.1007/s10856-014-5169-5.


2013


  • Aydemir Sezer U, Arslantunalı D, Aksoy EA, Hasırcı V, Hasırcı N. 2013. Poly(e-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications. Journal of Applied Polymer Science, DOI: 10.1002/APP.40110
  • D. Arslantunali, G. Budak, V. Hasirci. 2013, "Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair", Society for Biomaterials, DOI:10.1002/jbm.a.34727
  • Pinar Yilgor Huri, Gazi Huri, Umit Yasar, Yurdanur Ucar, Nurten Dikmen, Nesrin Hasirci, Vasif Hasirci, A Biomimetic Growth Factor Delivery Strategy for Enhanced Regeneration of Iliac Crest Defects, Biomedical Materials,(doi:10.1088/1748-6041/8/4/045009)
  • Seniz Ucar, Pinar Yilgor, Vasif Hasirci, Nesrin Hasirci, Chitosan Based Wet Spun Scaffolds for Bioactive Agent Delivery in Bone Tissue Engineering, J. Appl. Polm. Sci, (doi:10.1002/APP.39629)
  • P.Yilgor, G.Yilmaz, M.B.Onal, I.Solmaz, S.Gundogdu, S.Keskil, R.A.Sousa, R.L.Reis, N.Hasirci, V.Hasirci, An in vivo Study on Effect of Scaffold Geometry and Growth Factor Release on the Healing of Bone Defects, J Tissue Eng Regen Med, (doi: 10.1002/term.1456)
  • H.Bayram, H.Kenar, F.Tasar, V.Hasirci, Effect of low level laser therapy and zoledronate on the viability and ALP activity of Saos-2 cells, Int. J. Oral Maxillofac. Surg 42 (1), 140, 2013

  • A. Luca, B. Cilek, V. Hasirci, S. Sahin, G. Sumnu, Storage and Baking Stability of Encapsulated Sour Cherry Phenolic Compounds Prepared from Micro- and Nano-Suspensions, Food Bioprocess technology, 7(1)  2494-2502, 2013

  • A. B. Ertan, P. Yılgor, B. Bayyurt, A. C. Çalıkoğlu, Ç. Kaspar, F. N. Kök, G. T. Köse, V. Hasirci, Effect of double growth factor release on cartilage tissue engineering,  7, 149-160, 2013

  • H. Bilgic, M. Demiriz, M. Ozler, Tayfun Ide, N. Dogan, S. Gumus, A. Kiziltay,T. Endogan, V. Hasirci, N. Hasirci, Effects of EGF Containing Gelatin Sponges as Wound Healing Scaffolds”, J. Biomater. Tissue Eng., 3, 2, 205-211, April, 2013
  • Albana Ndreu Halili, Nesrin Hasirci, and Vasif Hasirci, A Mechanically Functional Collagen-Based Construct Designed as a Meniscus Substitute, J. Biomater. Tissue Eng. 3, 2, 173-184, April, 2013
  • Ozgen, O., Aksoy, E. A., Hasirci, V., Hasirci, N., Surface Characterization and Radical Decay Studies of Oxygen Plasma Treated PMMA Films, Surface and Interface Analysis, Surf. Interface Anal., 45, 844–853, Feb, 2013
  • Sezer, U. A., Aksoy, E. A., Hasirci, V., Hasirci, N., Poly(ε-caprolactone) composites containing gentamicin loaded β-TCP/Gelatin microspheres as bone tissue supports, J Appl Polym Sci, 127: 2132–2139, Jan, 2013


2012


  • Ozgen, O., Aksoy, A., Hasirci, H., Hasirci N. 2012, "Surface characterization and radical decay studies of oxygen plasma-treated PMMA films", Journal of Surface and Interface Analysis, DOI: 10.1002/sia.5181.
  • Karadas, O., Yucel D., Kenar, H., Kose, G., Hasirci, V. 2012, "Collagen scaffolds with in situ-grown calcium phosphate for osteogenic differentiation of Wharton’s jelly and menstrual blood stem cells", Journal of Tissue Engineering and Regenerative Medicine, DOI: 10.1002/term.1555.
  • A. Küçükturhan, V. Hasırcı, Ürolojide nanoteknoloji uygulamaları, in Moleküler Üroloji, Eds. L. Turkeri, A. Ozer, F. Narter, Publisher Uronkoloji Dernegi, Istanbul (Turkey), pp.711-720, 2012, ISBN 978-975-01697-2-4 
  • M. Ermis, G. Bahcecioglu, B. Kandemir, V. Hasirci, Kök hücreler, rejeneratif üroloji, ve doku mühendisliği, in Moleküler Üroloji, Eds. L. Turkeri, A. Ozer, F. Narter, Publisher Uronkoloji Dernegi, Istanbul (Turkey), pp. 721-748, 012, ISBN 978-975-01697-2-4 
  • Hasirci, V. & Pepe-Mooney, B.J. 2012, "Understanding the cell behavior on nano-/micro-patterned surfaces", Nanomedicine (London, England), DOI 10.2217/NNM.12.7
  • Luca, A., Cilek, B., Hasirci, V., Sahin, S., & Sumnu, G. 2012 "Effect of degritting of phenolic extract from sour cherry pomace on encapsulation Efficiency—Production of Nano-suspension", Food Bioprocess Technol, DOI 10.1007/s11947-012-0880-z 
  • Sezer, U.A., Aksoy, E.A., Hasirci, V. & Hasirci, N. 2012, "Poly(ε-caprolactone) composites containing gentamicin-loaded  β -tricalcium phosphate/gelatin microspheres as bone tissue supports", Journal of Applied Polymer Science, DOI: 10.1002/app.37770. [
  • Yilgor, P., Yilmaz, G., Onal, M.B., Solmaz, I., Gundogdu, S., Keskil, S., Sousa, R.A., Reis, R.L., Hasirci, N. & Hasirci, V. 2012, "An in vivo study on the effect of scaffold geometry and growth factor release on the healing of bone defects", Journal of tissue engineering and regenerative medicine  DOI: 10.1002/1456 .
  • Kinikoglu, B., Rovere, M.R., Haftek, M., Hasirci, V. & Damour, O. 2012, "Influence of the mesenchymal cell source on oral epithelial development", Journal of Tissue Engineering and Regenerative Medicine, vol. 6, no. 3, pp. 245-252.
  • Isikli, C., Hasirci, V. & Hasirci, N. 2012, "Development of porous chitosan/gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applications", Journal of Tissue Engineering and Regenerative Medicine, vol. 6, no. 2, pp. 135-143.
  • B. Bayyurt, V. Hasirci, The Antiproliferative Effect of Celecoxib Loaded, J.  Biomat and TE, 2, 1–8, 2012
  • B. Cilek, A. Luca, V. Hasirci, S. Sahin, G. Sumnu, Microencapsulation of phenolic compounds extracted from sour cherry pomace effect of formulation, ultrasonication time
and core to coating ratio,  235:587-596, DOI 10.1007/s00217-012-1786-8-2012
  • B. Kinikoglu, J. Hemar, V. Hasirci, P, Breton, O. Damour, Feasibility of a porcineoralmucosaequivalent- a preclinical study,Artificial Cells Blood Substitutes and Biotechnology, Early Online 1-4 
  • E. Vardar-M. Vert, J. Coudane-V. Hasirc, N. Hasirci, Porous agarose based semi IPN hydrogels. JBSPE 23(18), 2273-2286

  • H.Bayram, H.Kenar, F.Tasar, V.Hasirci, Effect of low level laser therapy and zoledronate on the viability and ALP activity of Saos-2 cells. Int. J. Oral Maxillofac, 42, (1), 140-146, 2012

  • T Endogan A Kiziltay V Hasirci Nesrin Hasirci_Modification of acrylic bone cements with oxygen plasma and additives J Biomaterials and Tissue Engineering 2-236-243

  • U. A. Sezer, E.A. Aksoy, V.Hasirci, N.Hasirci, Poly(e-caprolactone) Composites Containing Gentamicin-Loaded, beta-Tricalcium PhosphateGelatin Microspheres as Bone Tissue Supports, Journal of Applied Polymer Science, DOI: 10.1002/app.37770


2011


  • B.Demirbag, P.Y. Huri, G.T. Kose, A. Buyuksungur, V.Hasirci,Advanced Cell Therapies With and Without Scaffolds, Biotechnology Journal, 6(12), 1437-1453, 2011

  • B. Kinikoglu, J.C Rodriguez-Cabello, O. Damour,  V.Hasirci, A smart bilayer scaffold of elastin-like recombinamer and collagen for soft tissue engineering, J Mater Sci: Mater Med 22:1541–1554, 2011

  • Kinikoglu B, Rodríguez-Cabello JC, Damour O, Hasirci V., The influence of elastin-like recombinant polymer on the self-renewing potential of a 3D tissue equivalent derived from human lamina propria fibroblasts and oral epithelial cells, Biomaterials,32(25):5756-64, 2011.
  • Kenar H, Kose GT, Toner M, Kaplan DL, Hasirci V., A 3D Aligned Microfibrous Myocardial Tissue Construct Cultured under Transient Perfusion, Biomaterials, 32(23):5320-5329, 2011

  • E. Aydin, J. A. Planell, V. Hasirci, Hydroxyapatite Nanorod - Reinforced Biodegradable Poly(L-lactic acid) Composites for Bone Plate Applications, J Materials Science: Materials in Medicine 22(11), 2413-2427, 2011
  • E. Carletti, T. Endogan, N. Hasirci, V. Hasirci, D. Maniglio, A. Motta,C. Migliaresi, Microfabrication of PDLLA scaffolds, J Tissue Engineering and Regenerative Medicine,  5: 569–577, 2011 
  • C. Padeste, H. Özçelik, J. Ziegler, A. Schleunitz, M. Bednarzik, D. Yücel , V. Hasırcı, Replication of high aspect ratio pillar array structures in biocompatible polymers for tissue engineering applications, Microelectronic Engineering 88 1836–1839, 2011
  • V. Hasirci, P. Yilgor, T. Endogan, G. Eke, N. Hasirci, Polymer Fundamentals: Polymer Synthesis, Comprehensive Biomaterials, 1, 349-371, 2011

 

2010

 

  • P. Yilgor, R.A. Sousa, R.L Reis, N. Hasirci, V. Hasirci, Effect of scaffold architecture and BMP2 BMP7 delivery on in vitro bone regeneration, J Mater Sci Mater Med., 21(11):2999-3008, 2010.
  • P. Zorlutuna, P. Vadgama, V. Hasirci, Both sides nanopatterned tubular collagen scaffolds as tissue-engineered vascular grafts,Journal of Tissue Engineering and Regenerative Medicine,4 (8), 628-637,2010.
  • D. Yucel, G.T. Kose, V. Hasirci, Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes, Biomacromolecules, 11(12):3584-3591,2010
  • B. Shokouhi, C. Coban, V. Hasirci, E. Aydin, A. Dhanasingh, N. Shi, S. Koyama, S. Akira, M. Zenke, A. S. Sechi, The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells, Biomaterials xx 1-13, 2010.
  • P.Yilgor, N.Hasirci, V.Hasirci, Sequential BMP-2/BMP-7 Delivery from Polyester Nanocapsules, J Biomed Mater Res 93A, 528-536, 2010.
  • D.Yucel, G.T.Kose, V.Hasirci, Polyester based nerve guidance conduit design, Biomaterials 31(7), 1596-1603, 2010.
  • P.M.Davidson, O.Fromigué, P.J. Marie, V.Hasirci, G. Reiter, K.Anselme, Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms, J Mater Sci: Mater Med 21(3), 939-946, 2010.
  • H. Kenar, G.T.Kose, V.Hasirci, Design of a 3D aligned myocardial tissue construct from biodegradable polyesters, J Mater Sci: Mater Med 21(3), 989-997, 2010. 

 

2009

 

  • B.Kinikoglu, C.Auxenfans, P.Pierrillas, V.Justin, P.Breton, C.Burillon, V.Hasirci, O.Damour, Reconstruction of a full-thickness collagen-based human oral mucosal equivalent, Biomaterials 30(32), 6418-6425, 2009.
  • P.M.Davidson, H.Ozcelik, V.Hasirci, G.Reiter, K.Anselme, Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus, Adv Mater 21, 3586-3590, 2009.
  • N.Ozturk, A.Girotti, G.T.Kose, J.C.Rodriguez-Cabello, V.Hasirci, Dynamic Cell Culturing and its Applicatıon to Micropatterned Elastin Like Protein-Modified Poly(N-Isopropylacrylamide) Scaffolds, Biomaterials 30(29), 5417-5426, 2009.
  • P.Yilgor, K.Tuzlakoglu, R.L.Reis, N.Hasirci, V.Hasirci, Incorporation of a Sequential BMP-2/BMP-7 Delivery System into Chitosan-Based Scaffolds for Bone Tissue Engineering, Biomaterials 30(21), 3551-3559, 2009.
  • P.Zorlutuna, Z.Rong, P.Vadgama, V.Hasirci, Influence of Nanopatterns on Endothelial Cell Adhesion: Enhanced Cell Retention under Shear Stress, Acta Biomater 5(7), 2451-2459, 2009.
  • P.Zorlutuna, P.Yilgor, F.B.Basmanav, V.Hasirci, Biomaterials and tissue engineering research in Turkey: The METU Biomat Center experience, Biotechnology Journal 4(7), 965-980, 2009.
  • P.Zorlutuna, A.Elsheikh, V.Hasirci, Nanopatterning of Collagen Scaffolds Improve the Mechanical Properties of Tissue Engineered Vascular Grafts, Biomacromolecules 10(4), 814-821, 2009.

 

Books:


  • Biomaterials: From Molecules to Engineered Tissue 

Edited By Nesrin Hasirci, Vasif Hasirci 
Kluwer Academic/Plenum Publishers 
Book Series: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY: Volume 553 
eBook, ISBN 0-306-48583-4, July 2004

 

  • Tissue Engineering and Novel Delivery Systems 

Edited By: Donald L. Wise; Vasif Hasirci; Kai-Uwe Lewandrowski; Michael J. Yaszemski; David E. Altobelli; Debra J. Trantolo 
Marcel Dekker, Print ISBN: 0-8247-4786-0 

 

  • Biomaterials in Orthopedics 

Edited By: Michael J. Yaszemski; Debra J. Trantolo; Kai-Uwe Lewandrowski; Vasif Hasirci; David E. Altobelli; Donald L. Wise 
Marcel Dekker 
Handbook | Print Published: 10/17/2003 
Print ISBN: 0-8247-4294-X

 

Guest Editor:

 

  • Macromolecular Symposia: Molecular Basis, Production and Applications of Biopolymers in Biotechnology, Biomedicine and Nanobiomaterials, Vol. 269, Wiley-Interscience 2008
  • Journal of Biomaterials Science Polymer Edition, Nanobiomaterials Special Edition Part 2. JPS 18(3), 2007
  • Journal of Biomaterials Science Polymer Edition Nanobiomaterials Special Edition Part 1. JPS 17(11), 2006


Patent:

 

  • Daniel B.Carr, Andrej W.Lipkowski, Donald L.Wise, Vasif Hasirci, Drug Delivery Composition, U.S. Patent 6.913.760, Jul 5, 2005 
  • V.Hasirci and D.Keskin, Poly-4-Hydroxybutyrate Matrices for Sustained Drug Delivery, Provisional Application for U.S. Letters Patent, 2003, (WO/2005/007195) 

 

Patent application:

 

  • V. Hasirci, E. Vrana, P. Zorlutuna, Stacked, Patterned Biomaterials and/or Tissue Engineering Scaffolds, Türk Patent Enstitüsü, Application March 15, 2007

 

Editorial Board Membership:

 

  • Biomaterials 
  • Journal of Biomaterials Science: Polymer Edition 
  • Nanomedicine
  • Tissue Engineering and Regenerative Medicine 
  • The Open Biomedical Engineering Journal