BİOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


BIO 554 - Macromolecules in Biotechnology and Biomedicine

 

Credits:  (3-0) 3
Prerequisite:  Consent of the Instructor

 

Goals:

 

Classification, synthesis and transformation of biopolymers (polynucleotides, polypeptides and polysaccharides). Merrifield solid state synthesis. Classification, synthesis and transformation of synthetic macromolecules. Chemical and biological transformation. Solution behavior, helix-coil transition. Structure, morphology and properties of biological polymers in the solid state. Single crystal formation. Applications in Biomedicine and Biotechnology.(S/WE)*

 

Course Outline:

 

  • Introduction
  • Classification of Macromolecular Compounds
  • MW and Polymolecularity
  • Synthesis of Synthetic Polymers
  • Synthesis of Macromolecules With Heteroatoms In The Chain Via Polycondensation
  • Solid State Synthesis of Proteins
  • Strategies For Chemical Synthesis of DNA
  • Chemical Transformation
  • The Macromolecular Solution
  • The Peptide Bond Structure and Morphology of Biopolymers
  • a-Helix and Single crystal
  • Free Energies, Bonding Types and Conformation
  • Packing density
  • Macromolecular Symmetry
  • Specific Biopolymers
  • Recent Papers

 

Reference Books:

 

  • Biotechnology and Bioactive Polymers, C.G.Gebelein, C.H.Carraher, Jr., Plenum Press, 1994
  • Immobilized Macromolecules, U.B.Sleyr, P.Messner, D.Pum, M.Sara, Springer- Verlag,1993
  • Biosensors, A.E.G.Cass, IRL Press,1990
  • Biopolymers, A.G.Walton, J.Blackwell, S.H.Carr, Academic Press, 1973
  • Biophysical Chemistry, C.R.Cantor, P.R.Schimmel, W.H.Freeman and Co.,1980
  • Polysaccharides, E.D.T.Atkins, Macmillan,1985